This course delves into the pathophysiological mechanisms and material science aspects of total hip arthroplasty (THA). Through a series of clinically oriented multiple-choice questions, learners explore cytokine-mediated osteolysis, macrophage and lymphocyte responses to wear debris, and the mechanical behavior of implant materials such as polyethylene, ceramics, and metal alloys.

The content integrates both molecular biology and clinical orthopedics, enabling trainees to correlate radiographic findings with underlying cellular mechanisms such as RANK/RANKL signaling, TNF-alpha and IL-1 activation, and prosthesis wear patterns.

By mastering these principles, participants will gain the ability to identify causes of implant loosening, evaluate material performance, and understand the biological responses influencing long-term arthroplasty outcomes.